What it means
To worry, fuss, or nag someone repeatedly. Mancunian through and through. If your mum is mithering you, she is pestering you about something you were definitely going to do eventually. If you are mithering, you are stressing about something that probably is not worth the energy. Stop mithering is Manchester's version of calm down and let it go.
Usage examples
"She's been mithering me all morning about the leaky tap. I said I would fix it after the match but apparently after the match is not an acceptable timeframe."
"Stop mithering me about the remote, the match is nearly over and then you can watch your cartoons, I promise."
Where it comes from
A proper Northern word, big in Manchester, meaning to pester, fuss or worry at someone until they crack. It can also mean to be in a flap yourself, all mithered and frazzled. Nobody quite agrees where it came from, but everyone up North knows exactly what it feels like to be mithered by a five year old.
Other ways to say it
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